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|Title: ||EFFECT OF CAPSICUM FRUTESCENS AND CAPSICUM ANNUM ON GASTRIC ACID SECRETION IN WISTAR RATS|
|Authors: ||AKWARAS, NNDUNNO ASHEKU|
|Keywords: ||CAPSICUM FRUTESCENS, CAPSICUM ANNUM|
GASTRIC ACID, SECRETION, WISTAR RATS
|Issue Date: ||Oct-2019|
|Abstract: ||Introduction: The effect of ingested food substances has been of interest to gastroenterologists. Capsicum frutescens and Capsicum annum (CA) are peppers that are commonly used as spices in meals and contain capsaicin as their main principle. Methodology: The effect of Capsicum frutescens (CF) and Capsicum annum (CA) were studied using 96 wistar rats of both sexes weighing between 200-300g. Aqueous extracts of CF and CA were administered through a fundal gastric fistula. Doses of 10 %, 20 %, 30 % of LD 50, 10 mg, 20 mg, 30 mg, 40 mg, 50 mg, 60 mg, 70 mg and 80 mg per 100 g body weight of the aqueous extract were given. Gastric acid was measured by collecting 10 mls aliquot sample of gastric contents over 10 minutes and titrating with 0.01N NaOH to phenolphthalein end point. Samples were collected for over 120 minutes. Results: The result showed acid secretory response in mmol/l/hr for CF versus (vs) CA were basal acid output ( BAO) of 16.02 ± 0.01 vs 15.6 ± .19. It was observed that gastric acid secretion increased stepwise and was time dependent rising to a crescendo between 50 and 70 minutes vs 40 and 80 minutes for CF vs CA. Thereafter the secretory response rose to a plateau and was called saturation phenomenon. Acid secretion then declined between 80 and 120 minutes. This decline was termed tachyphylaxis. CF caused more acid secretion than CA at doses 50, 60, 70 and 80mg. At a dose of 30% LD50 of CF an asynchronous response with no clear decline was observed and was termed idiosyncracy.
Conclusion: It was concluded that acid secretory response is dose and time dependent and it demonstrates saturation phenomenon, idiosyncracy and tachyphylaxis.|
|Appears in Collections:||Physiology|
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